Nematode anticoagulant protein targets blood coagulation factor.

2003 NOV 20 - (NewsRx.com & NewsRx.net) -- Recombinant nematode anticoagulant protein c2 targets blood coagulation factor VIIa/tissue factor.

According to a study from Canada, "Originally isolated from a hematophagous hookworm, recombinant nematode anticoagulant protein c2 (rNAPc2) is an 85-amino acid protein with potent anticoagulant properties. Unlike conventional anticoagulants that attenuate blood coagulation via inhibition of thrombin or activated factor X (FXa) at the downstream portion of the cascade, rNAPc2 is a potent inhibitor of the activated factor VII/tissue factor complex (FVIIa/TF), the key physiological initiator of blood coagulation."

"Its …